The USS Enterprise NCC-1701 was a Federation Constitution-class heavy cruiser that was in service with Starfleet in the mid-to-late 23rd century. In the course of her career, the Enterprise became the most celebrated starship of her time.
Captain Christopher Pike commanded the Enterprise from the early 2250s into the 2260s.
In 2265, the Enterprise was assigned to a five-year mission of deep-space exploration, and command passed to James T. Kirk.
In her forty years of service and discovery, through upgrades and at least two refits, she took part in numerous first contacts, military engagements, and time-travels. She achieved her most lasting fame from the five-year mission (2265-2270) under the command of James T. Kirk.
The Enterprise was destroyed over the Genesis Planet in 2285. Star Trek III: The Search for Spock
Captain Robert April (2245)
Captain Christopher Pike (2250s through early 2260s)
Captain James T. Kirk (2265-2270; as rear admiral in early 2270s)
Captain Willard Decker (during refit and shakedowns in early 2270s)
Captain Spock (2281 through 2285)
Admiral James T. Kirk (during the Khan crisis of 2285)